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Researchers Find Earliest Known Signs of Alzheimer’s in People with Genetic Mutation that Causes Inherited Form of the Disease

Researchers have found the earliest signs of Alzheimer’s disease yet detected in a group of people with a rare, inherited form of the disease, according to two Articles published in The Lancet Neurology. The findings raise important questions about scientists’ understanding of how, and why, Alzheimer’s disease progresses, and could ultimately lead to improved early detection and better clinical trials of preventative treatments.

Alzheimer’s Consortium Identifies Five New Genes for Disease Risk

The Alzheimer’s Disease Genetics Consortium (ADGC) led by the University of Pennsylvania School of Medicine, the University of Miami, and the Boston University School of Medicine, recently identified five new genes linked to late-onset Alzheimer’s disease. The study, published in the journal Nature Genetics, describes data on ABCA7, MS4A6A/MS4A4E, CD2AP, CD33 and EPHA1, each of which contribute to the risk of dementia later in life.