Quantcast

Industry news that matters to you.  Learn more

Veristat to Assist on Adaptive Enrichment Trial for Verastem’s Defactinib in Mesothelioma

Veristat, LLC., a leading, Boston-based clinical research organization, recently announced its advisory role on the implementation of an adaptive enrichment trial design for Verastem, Inc. (NASDAQ: VSTM). The enhanced design aims to optimize the current trial of defactinib, a novel, small molecule inhibitor of focal adhesion kinase (FAK) in patients with malignant pleural mesothelioma.

“We have identified a biomarker in mesothelioma that may predict increased sensitivity to defactinib,” said Dr. Joanna Horobin, Chief Medical Officer at Verastem. “We felt strongly that the application of an enrichment design would help us to accelerate the program to a potential regulatory decision. We are excited to have Veristat’s experience in enrichment trial design and execution supporting this trial.”

Veristat’s input on the overall trial design, as well as the adaptive enrichment design architecture and planned analyses will help facilitate decisions required at key development intersections of the program.

“The Verastem clinical development team has taken a dynamic approach to the design of this study,” commented Dr. John Balser, president and chief science officer at Veristat. “Our team at Veristat will be assisting them with the statistical and operational challenges inherent in the adaptive enrichment design architecture. Our goal is to produce a trial that will quickly and cost effectively yield the highest likelihood of success for their target patient population.”

Source: Veristat

High Levels of Blood-Based Protein Specific to Mesothelioma

Researchers at NYU School of Medicine have discovered the protein product of a little-known gene may one day prove useful in identifying and monitoring the development of mesothelioma in early stages, when aggressive treatment can have an impact on the progression of disease and patient prognosis.

Discovery and Validation of a Blood-based Protein Signature for Early Detection of Mesothelioma

A multi-institute team of researchers led by scientists at the NYU Langone Medical Center and SomaLogic, Inc., announced today the discovery and validation of a panel of 13 blood-based protein biomarkers that can detect malignant mesothelioma in even the early stages of this rare but deadly cancer. The work, which is based on a new protein measurement technology developed by SomaLogic, is published today in the open-access scientific journal PLOS ONE.

Cancer Biomarker Study Data Presented at the 2011 AACR Meeting

A roundup of five research studies on cancer biomarkers that were presented earlier this week at the American Association for Cancer Research (AACR) 102nd Annual Meeting in Orlando, Florida.