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HTG/Sanofi US Annouce Biomarker Collaboration

HTG Molecular Diagnostics has established a collaborative program with Sanofi US to identify biomarkers that may lead to the development of a molecular companion diagnostic test to help identify patients most likely to respond to a novel Sanofi investigational agent. HTG Molecular Diagnostics’ qNPA technology measures mRNA and/or miRNA expression in formalin fixed paraffin embedded (FFPE) tumor samples, allowing clinicians to verify the presence of certain biomarkers relevant to patient selection and therapy.

NextGen Files for Intellectual Property on Dementia Biomarkers

NextGen Group Plc (AIM: NGG), an AIM listed company providing biomarker discovery services and diagnostic assay development, announces that its subsidiary, NextGen Sciences Dx (NGSDx), has filed for intellectual property (IP) on a combination of protein biomarkers with the potential for diagnosing changes in cognition for patients with early-stage dementia.

OncoSec and Serametrix Collaborate to Identify Potential Biomarkers to Enhance Skin Cancer Immune Therapies

OncoSec Medical Incorporated, which is developing its advanced-stage OMS ElectroOncology therapies to treat solid tumor cancers, today announced it has entered into a collaborative research agreement with Serametrix Corporation to analyze subjects in three OncoSec Phase II clinical trials treating melanoma, Merkel cell carcinoma and cutaneous T-cell lymphoma with the goal of identifying biomarkers that may refine and enhance the selection of patients potentially responsive to these treatments. Terms of the final agreement have not been released.

Clarient Joins the HistoRX Clinical Trials Network

Clarient, a GE Healthcare company, and HistoRx, Inc., have signed a definitive agreement to provide pharma services using AQUA technology to their growing lists of pharma clients. By implementing HistoRx’s AQUA technology in Clarient’s CLIA laboratory, the two companies will apply their complementary capabilities to serve pharma companies’ growing need for biomarker analysis in clinical trials. Use of tissue biomarkers to characterize a patient’s tumor is becoming a crucial element of personalized cancer care. AQUA technology is an automated, quantitative IHC testing method that enables standardized precision measurement of protein biomarkers in tissue as an aid to a pathologist’s diagnosis.

Skyline Diagnostics, Clavis Pharma to Collaborate on Patient Selection Biomarker Discovery for Leukemia Drug Elacytarabine

The Dutch biotech company Skyline Diagnostics B.V. (Skyline) and the Norwegian drug development company Clavis Pharma ASA (Clavis) disclosed signing a research agreement. Under this agreement, Skyline will investigate gene expression biomarkers for selection of individual Acute Myeloid Leukemia (AML) patients that may benefit from a new AML drug in development at Clavis. This drug, elacytarabine, is a novel elaidic acid derivative of cytarabine and currently undergoing the CLAVELA phase III study for treatment of patients with relapsed/refractory AML.