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Biomarker for Oxidative Stress Plays a Major Role in Hepatic Inflammation

Diet-related diseases like non-alcoholic fatty liver disease (NAFLD) are known to have a major inflammatory component. However, the molecular pathways linking diet-induced changes with inflammation remained elusive. In a new study, Christoph Binder’s Group at CeMM and the Medical University of Vienna identified crucial inflammatory processes in NAFLD and found that malondialdehyde (MDA), a biomarker for oxidative stress, plays a key role in the development of NAFLD and can be neutralized by specific natural antibodies – a novel approach towards a potential therapy for the prevalent disease.