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Caris Life Sciences and COTA Enter Collaboration to Measure Clinical and Economic Impact of Evidenced-Based Drug Selection for Precision Medicine in Oncology

Caris Life Sciences® today announced a strategic collaboration with COTA, Inc. (Cancer Outcomes Tracking & Analysis) to capture genomic and proteomic molecular data along with clinical information and outcomes data, to measure the health and economic impact of Caris Molecular Intelligence®, the company’s panomic, comprehensive tumor profiling service, for cancer patients. Under the agreement, Caris Life Sciences and COTA will track and combine de-identified molecular data and clinical outcomes in a longitudinal database that is intended to be expanded across the Caris Centers of Excellence for Precision Medicine Network (COE Network).

Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer

Caris Life Sciences® today announced the presentation of study data in small cell cervical cancer (SCCC) that shows multiplatform tumor profiling using Caris Molecular Intelligence®, the company’s panomic, comprehensive tumor profiling service, identified high expressions of certain gene mutations which may explain sensitivities and resistance to common drug therapies. Researchers found that identification of certain biomarkers may guide treatment strategies in rare, aggressive and difficult to treat gynecological cancers. The data was presented during Poster Session B on Sunday, March 29, at the Society of Gynecologic Oncology (SGO) annual meeting on Women’s Cancers in Chicago, Ill.

Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers

Caris Life Sciences® today announced the presentation of two studies in which Caris Molecular Intelligence®, the company’s panomic, comprehensive tumor profiling service, found that molecular similarities and differences between several rare and difficult to treat gynecological cancers may inform targeted treatment strategies that have the potential to improve patient outcomes. These studies were presented today during Poster Session B at the Society of Gynecologic Oncology (SGO) 2015 Annual Meeting on Women’s Cancer in Chicago, Ill.

Caris Life Sciences’ Multiplatform Tumor Profiling Technology Identifies Expression of PD-1 and PD-L1 in Gynecologic Malignancies

Caris Life Sciences® today announced the presentation of important study data showing the presence of PD-1 and PD-L1 expressing cells in 1,599 gynecologic cancer samples. Using Caris Molecular Intelligence®, the company’s panomic comprehensive tumor profiling service, researchers identified expression of programmed cell death protein-1 (PD-1) in all gynecologic cancers independent of histology while its ligand (PD-L1) expression was variable across malignancies and histologies. This data, along with two separate studies utilizing Caris Molecular Intelligence in the identification of druggable biomarkers in cervical cancers, were presented today during Poster Session B, at the Society of Gynecologic Oncology 2015 Annual Meeting on Women’s Cancers in Chicago, Ill. 

Caris Life Sciences Study Shows Molecular Profiling May Expand Use of PD-1 and PD-L1 Inhibitors to Wide Variety of Cancers

Caris Life Sciences, a biosciences company focused on fulfilling the promise of precision medicine, recently announced the publication of a study in which Caris Molecular Intelligence™, the company’s panomic, comprehensive tumor profiling service, demonstrated the utility of exploring the expression of two potentially targetable immune checkpoint proteins – the programmed cell death protein 1 (PD-1) and its ligand, PD-L1 – in a substantial proportion of solid tumors. The study results, published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, may expand the use of PD-1 and PD-L1 inhibitors, a new class of anticancer drugs, to a wide variety of solid tumors, including some aggressive subtypes that lack targeted treatment regimens.