Industry news that matters to you.  Learn more

BioTime and OncoCyte Corporation Publish Data on the Gene COL10A1 as a Marker and Potential Diagnostic for a Wide Array of Human Cancers

Reading time: 2 – 4 minutes

BioTime, Inc. (NYSE MKT: BTX) and BioTime’s subsidiary OncoCyte Corporation today announced the publication of a scientific report on the gene COL10A1 and its potential as a marker for numerous types of human cancers. The paper, published in the peer-reviewed journal Future Oncology and available online today, describes the microarray-based approach used to identify COL10A1 as a pan-cancer biomarker with significantly elevated expression in diverse malignant tumor types including cancers of the breast, stomach, colon, lung, bladder, pancreas, and ovaries. In addition, the protein was shown to be specifically localized within tumor vasculature. Combined, these findings will be an important basis for the development and application of new diagnostic and therapeutic strategies, including the measurement of Collagen Type X in the blood as a screen for the presence of cancer, the use of antibodies that recognize and bind to the protein to visualize and locate tumors in the body, and the targeted delivery of tumor-destroying agents.

“These findings are significant on several levels,” said Karen Chapman, PhD, Director of Bioinformatics at OncoCyte and lead author of the report. “COL10A1, the gene that encodes Collagen Type X, is normally only expressed in a specific zone within developing bones and is generally not expressed in most adult cells and tissues. This low background expression, taken together with the significant expression that we observed in many tumor types, underscores the potential use of this biomarker as a novel diagnostic and therapeutic target for many cancer types.”

“As a result of the studies described in today’s publication, OncoCyte has generated five proprietary monoclonal antibodies to Collage Type X for use in developing novel cancer diagnostics, imaging agents and targeted therapeutics,” said Joseph Wagner, PhD, CEO of OncoCyte and co-author of the study. “Given the broad expression of this protein across numerous tumor types and its association with tumor vasculature, characterization of this marker in cancer patients’ blood samples has become a priority at OncoCyte. Upon validation of their performance in detecting cancers from patient samples, these antibodies are candidates for inclusion in PanC-Dx, a low-cost, easy-to-use product with broad cancer detection ability slated for launch in 2014.”

PanC-Dx is being developed to detect the presence of a variety of human cancers, including cancers of the breast, lung, bladder, uterus, stomach, and colon, during routine check-ups. By facilitating early non-invasive cancer detection through a blood test, PanC-DxTM could lead to more successful therapeutic outcomes while simultaneously reducing the costs of cancer monitoring and globally increasing the availability of affordable cancer screening. OncoCyte first announced the development of PanC-Dx during December 2011 and intends to launch the product in Europe in 2014 before seeking the required approval by the Food and Drug Administration to market PanC-Dx in the United States.

Source: COL10A1 expression is elevated in diverse solid tumor types and is associated with tumor vasculature

Source: Business Wire