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Archives for December 2010

Tau Linked to a Specific Brain Area and Function in Alzheimer’s Disease

Earlier this week, University of Minnesota researchers said that they have established a firm relationship between the Tau protein and Alzheimer’s disease. Tau has long been considered a biomarker for onset of Alzheimer’s disease.

Biomarkers May Predict Death in AIDS Patients with Severe Inflammation

HIV, which causes AIDS, infects and kills immune system cells, eventually making the immune system so weak that “opportunistic” infections – infections that take advantage of the opportunity offered by a weakened immune system – begin to occur. One common opportunistic infection in AIDS patients is cryptococcal meningitis, a fungal infection around the brain. Approximately one million cases of cryptococcal meningitis occur every year.

Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated inflammatory immune response that kills up to one-third of affected people. AIDS patients with cryptococcal meningitis who start HIV therapy are predisposed to IRIS. A study in this week’s PLoS Medicine (link below) suggests that a panel of blood biomarkers, which show evidence of a damaged immune system that is not capable of clearing the fungal infection, can be used to stratify AIDS patients by risk for IRIS.

Myriad Genetics Launches Panexia Predictive Test for Hereditary Pancreatic and Related Cancers

Myriad Genetics, a molecular diagnostic company focused on developing and marketing novel predictive medicine, personalized medicine and prognostic medicine products, announced today the launch of Panexia, a predictive medicine product for hereditary pancreatic and related cancers.

Metamark Genetics and HistoRX Announce Licensing Agreement for AQUA Technology

Metamark Genetics, Inc., a privately held molecular diagnostics company focused on oncology, and HistoRx, Inc., a tissue-based diagnostics company, yesterday announced a multi-year licensing agreement. Metamark has been granted a worldwide license to the AQUA technology by HistoRx for the clinical commercialization of Metamark’s proprietary MetamarkDx Prognostic Assays.

Proteome Sciences Enters into Research Contract with Janssen Pharma

Proteome Sciences announced yesterday that it has entered into a research contract with Janssen Pharmaceutica NV, a J&J company.